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Excellent work that will prove an invaluable tool for both research and treatment for all psychiatric professionals and students. Covers all aspects of treatment-resistant depression: causes, epidemiology, comorbidity, evaluation and treatment.

There is little published information available to clinicians for diagnosis and management of treatment-resistant depression, so they have had to make difficult decisions about treatment options with very limited data. While antidepressants have helped millions worldwide, a substantial proportion of patients fail to respond or remit.

The editors and their international team of contributors have set out to address this problem, giving a critical assessment of all aspects of treatment-resistant depression: causes, epidemiology, comorbidity, evaluation and treatment.

• Editors and contributors are among the leading experts in the world


• A systematic and comprehensive review of an often neglected area


• Essential reading for professionals in the field

Review:'The excellence of this book is the section on special patient populations. They are all extremely well covered … This book will be valuable for researchers, academics who are interested in the scholarly reviews and algorithms of treatments, clinicians with special interest in affective disorders, and any clinician who would like a valuable resource book in their library.'- International Journal of Geriatric Psychiatry

Contents

The Clinical Problem

• The characterization and definition of treatment-resistant mood disorders

• Overview of treatment-resistant depression and its management

Biological Basis

• Psychoneuroendocrine aspects of treatment-resistant mood disorders

• Estrogen and depressive illness in women

• Sleep abnormalities in treatment-resistant mood disorders

• Structural and functional brain imaging in treatment-resistant depression

• Immunologic factors in treatment-resistant depression

Treatment Approaches

• Selective serotonin reuptake inhibitors and serotonin-norepinephrine reuptake inhibitors in treatment-resistant depression

• Conventional and second generation monoamine oxidase inhibitors in treatment-resistant depression

• Drug combination strategies

• Electroconvulsive therapy in medication-resistant depression

• Thyroid augmentation

• Cognitive therapy and psychosocial interventions in chronic and treatment-resistant mood disorders

Special Patient Populations

• Chronic and refractory mood disorders in childhood and adolescence

• Treatment-resistant depression in the elderly

• Management of treatment-resistant depression during pregnancy and the postpartum period

• Preliminary algorithms for treatment-resistant bipolar depression

• Medical disorders and treatment-resistant depression

• Psychiatric comorbidity in treatment-resistant depression

• Suicide in treatment-refractory depression

Economic and Ethical Issues

• The economic impact of treatment non-response in major depressive disorders

• Ethical issues in research and treatment of patients with mood disorders