Essential to the management of patients suffering from neurological disorders is an understanding of the cognitive aspects of these conditions. This book begins with an outline of the various cognitive domains and how they can be tested, before covering in depth the cognitive deficits seen not only in prototypical neurodegenerative cognitive disorders (Alzheimer's disease, frontotemporal dementias, Huntington's disease, prionoses), but also in other common neurological disorders which may be complicated by cognitive impairment (stroke, multiple sclerosis, Parkinson's disease, brain tumours). This book is an essential reference text for all neurologists, not just those with an interest in cognitive disorders; and for general physicians and specialists who deal with any endocrine, metabolic, vascular, or infective disorders which may compromise cognitive function. Practitioners of professions allied to medicine which involve contact with cognitively impaired patients will also find this text useful.

Foreword

Preface

Acknowledgements

Part I. Cognitive Function, Neuropsychological Evaluation and Syndromes of Cognitive Impairment:

• 1.1. Attention


• 1.2. General Intelligence, IQ


• 1.3. Memory


• 1.4. Language


• 1.5. Perception


• 1.6. Praxis


• 1.7. Executive function - 'frontal function'


• 1.8. 'Bedside' neuropsychological test instruments


• 1.9. Normal aging


• 1.10. Dementia, delirium, depression


• 1.11. Cortical vs. subcortical dementia, thalamic dementia


• 1.12. Disconnection syndromes

Part II. Neurodegenerative Disorders:

• 2.1. Alzheimer's disease (AD)


• 2.2. Frontotemporal lobar degenerations (FTLD)


• 2.3. Motor neurone disease (MND), amyotrophic lateral sclerosis (ALS)


• 2.4. Dementia with Lewy bodies (DLB) and Parkinson's disease dementia (PDD)


• 2.5. Prion diseases


• 2.6. Mild cognitive impairment (MCI)

Part III. Cerebrovascular Disease - Vascular Dementia and Vascular Cognitive Impairment:

• 3.1. Cortical vascular dementia, Multi-infarct dementia (MID), poststroke dementia


• 3.2. Subcortical vascular dementia, Binswanger's disease, lacunar state, Subcortical ischaemic vascular disease (SIVD)


• 3.3. Strategic infarct dementia, strategic strokes


• 3.4. Subarachnoid haemorrhage (SAH)


• 3.5. Intracranial vascular malformations


• 3.6. Vasculopathies


• 3.7. Other cerebrovascular disorders

Part IV. The Epilepsies:

• 4.1. Epilepsy and cognitive impairment


• 4.2. Cognitive decline and epilepsy - shared aetiology


• 4.3. Seizures causing acquired cognitive impairment


• 4.4. Anti-epileptic drug therapy causing cognitive impairment


• 4.5. Treatment of cognitive problems in epilepsy

Part V. Neurogenetic Disorders:

• 5.1. Hereditary dementias


• 5.2. Hereditary ataxias


• 5.3. Hereditary spastic paraplegia


• 5.4. Hereditary movement disorders


• 5.5. Hereditary metabolic disorders


• 5.6. Hereditary neurocutaneous syndromes (phakomatoses)

Part VI. Inflammatory, Immune-mediated and Systemic Disorders:

• 6.1. Multiple sclerosis


• 6.2. Acute disseminated encephalomyelitis (ADEM)


• 6.3. Sarcoidosis


• 6.4. Systemic lupus erythematosus (SLE)


• 6.5. Sjogren's syndrome


• 6.6. Behcet's disease


• 6.7. Rheumatoid arthritis (RhA)


• 6.8. Scleroderma, systemic sclerosis


• 6.9. Relapsing polychondritis


• 6.10. Cerebral vasculitis


• 6.11. Sydenham's chorea, Paediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS)


• 6.12. Limbic encephalitis


• 6.13. Hashimoto's encephalopathy


• 6.14. Erdheim-Chester disease


• 6.15. Bilateral vestibulopathy

Part VII. Structural Brain Lesions:

• 7.1. Brain tumours and their treatment


• 7.2. Hydrocephalic dementias


• 7.3. Other structural lesions

Part VIII. Endocrine, Metabolic, and Toxin-Related Disorders

• 8.1. Endocrine disorders


• 8.2. Metabolic disorders


• 8.3. Toxin-related disorders

Part IX. Infective Disorders:

• 9.1. Encephalitides and meningoencephalitides


• 9.2. Meningitides


• 9.3. Human immunodeficiency virus (HIV) and related conditions


• 9.4. Other disorders of infective aetiology

Part X. Neuromuscular Disorders:

• 10.1. Myotonic dystrophy (Steinert disease)


• 10.2. Myasthenia gravis

Index